Used in immunological research to study T-cell activation and inflammatory responses. Helps in the development and testing of anti-inflammatory drugs and biologics targeting the TNF pathway. Commonly employed in receptor-ligand binding assays and functional studies involving immune cell signaling. The Fc tag enables easy detection and purification, and enhances stability and solubility in experimental systems. Widely applied in preclinical studies using non-human primate models due to species compatibility.