Used in immunological research to study immune cell signaling and interactions, particularly in the context of macrophage and dendritic cell regulation. This protein plays a key role in blocking phagocytosis by interacting with CD47, making it valuable for cancer immunotherapy studies where modulation of immune checkpoint pathways is required. Commonly applied in binding assays, protein-protein interaction studies, and development of therapeutic antibodies targeting the SIRPα-CD47 axis. Also utilized in preclinical testing due to its relevance in non-human primate models, providing translational data for human drug development.