Used in immunological research to study the role of GITR (Glucocorticoid-Induced TNFR-Related Protein, also known as TNFRSF18 or CD357) in T cell activation and regulation, particularly in non-human primate models such as Cynomolgus and Rhesus Macaque. Helps in understanding immune checkpoint pathways and developing therapies for autoimmune diseases, cancer, and chronic infections. The Fc tag enables detection, purification, and enhanced stability in assays. Commonly applied in binding studies, receptor-ligand interaction analysis, and in vitro functional assays to modulate immune responses.