Used in immunological research to study receptor tyrosine kinase signaling pathways involved in developmental processes and tissue homeostasis. Facilitates binding assays and protein-protein interaction studies due to the Fc tag, enabling easy detection and purification. Supports the development of therapeutic antibodies by serving as a target antigen in immunoassay development and validation. Commonly used in ELISA, flow cytometry, and surface plasmon resonance (SPR) to evaluate ligand-receptor interactions. Helps in assessing cross-reactivity of drug candidates in preclinical studies involving non-human primates.