Used in immunological research to study immune checkpoint pathways, particularly in non-human primate models. Helps in evaluating the interaction between PD-L2 and its receptors, contributing to the development of immunotherapies for cancer and autoimmune diseases. The Fc tag enables detection, purification, and potential modulation of immune cell activity in experimental settings. Commonly applied in binding assays, protein-protein interaction studies, and in vivo functional analyses.