Recombinant Cynomolgus/Rhesus Macaque TNFRSF10B (TRAILR2/CD262) with Fc tag, used in research to study TRAIL-induced apoptosis signaling pathways, particularly in preclinical cancer therapeutics development. This soluble receptor binds to TRAIL (TNF-related apoptosis-inducing ligand), acting as a decoy to inhibit its pro-apoptotic effects and enabling evaluation of cell death mechanisms in tumor cells. The Fc tag allows for easy detection, purification, and use in immunoassays, protein-protein interaction studies, flow cytometry, and ELISA. It supports biologics development and drug efficacy assessment in non-human primate models relevant to human diseases.