Used in immunological research to study immune cell signaling and interactions, particularly in the context of macrophage and dendritic cell regulation. Plays a key role in developing therapeutic strategies involving immune checkpoint pathways by serving as a binding partner for CD47. Commonly employed in protein-protein interaction assays, ELISA, and surface plasmon resonance (SPR) to measure binding kinetics. Also utilized in the production of antibodies and for validating targets in preclinical studies involving non-human primate models.