Used in immunological research to study receptor tyrosine kinase signaling pathways involved in embryonic development and tissue morphogenesis. Serves as a critical reagent in binding assays and protein-protein interaction studies, particularly in the development and validation of monoclonal antibodies targeting ROR2. The His tag facilitates easy purification and detection, making it valuable in recombinant protein expression systems. Commonly applied in preclinical studies using non-human primate models to assess therapeutic efficacy and safety of biologics targeting the ROR2 pathway, especially in cancers and skeletal disorders.