Used in immunological research to study the PVRIG pathway, which plays a key role in regulating T cell activation. This protein helps in understanding immune checkpoint mechanisms, particularly in the context of cancer immunotherapy. It serves as a tool for binding assays and functional studies involving the PVRIG ligand interaction, supporting the development of therapeutic antibodies. Commonly applied in in vitro assays to block or modulate immune responses, aiding in the evaluation of novel checkpoint inhibitors.