Used in immunological research to study cell adhesion and leukocyte trafficking due to its role in binding selectins. Facilitates assays involving protein-protein interactions, particularly in inflammation and immune response studies. Commonly employed in ELISA, flow cytometry, and protein purification workflows thanks to the Fc tag, which allows detection and immobilization using anti-Fc antibodies. Supports development of therapeutic strategies targeting PSGL-1 mediated interactions in autoimmune diseases and cancer metastasis.