Used in immunological research to study immune checkpoint pathways, particularly in non-human primate models. Facilitates the development and testing of therapeutic antibodies targeting the PD-L2 pathway. Supports binding affinity studies with receptors such as PD-1 and RGMb. Employed in ELISA, surface plasmon resonance (SPR), and flow cytometry assays to evaluate immune modulation. The His tag enables easy detection and purification, making it suitable for in vitro and in vivo studies related to autoimmunity, cancer immunotherapy, and infectious disease.