Used in immunological research to study natural killer (NK) cell activation and immune responses in non-human primates. The Fc tag enables easy detection and purification, making it valuable for binding assays, protein-protein interaction studies, and evaluation of therapeutic antibodies targeting the NKG2D pathway. Commonly applied in preclinical studies to assess immune modulation, cancer immunotherapy, and infectious disease mechanisms where NKG2D-ligand interactions play a role.