Used in immunological research to study natural killer (NK) cell and T-cell functions due to its role as a cell adhesion molecule. Facilitates the development of assays for cell-cell interaction, neural development, and tumor targeting. Commonly applied in flow cytometry, immunoassays, and protein-protein interaction studies. The His tag enables easy purification and detection, making it valuable for recombinant protein expression and therapeutic antibody screening in preclinical models.