Used in immunological research to study the interleukin-1 signaling pathway, particularly in non-human primate models. The Fc tag enables easy detection and purification, making it valuable for binding assays, protein interaction studies, and development of therapeutic antibodies targeting inflammation. Commonly applied in preclinical testing due to the close similarity of Cynomolgus and Rhesus Macaque proteins to human counterparts, supporting translational research in autoimmune diseases, sepsis, and chronic inflammatory conditions.