Used in immunological research to study purinergic signaling pathways, particularly in regulating extracellular ATP and ADP levels. Helps investigate immune suppression mechanisms in T cells and dendritic cells. Applied in studies of tumor microenvironment where CD39 expression contributes to immune evasion. Also utilized in autoimmune disease research, including models of inflammation and transplant rejection. The Fc tag enables easy detection and purification, and supports use in cell-based assays, ELISA, and flow cytometry. Plays a role in developing biologics and therapeutic antibodies targeting the CD39 pathway.