Used in immunological research to study the Delta-like protein 3 (DLL3) signaling pathway in non-human primates, particularly in preclinical development of targeted cancer therapies. The Fc tag enables easy detection and purification, and supports functional assays such as binding affinity analysis, flow cytometry, and ELISA. Commonly employed in studies assessing cross-reactivity of therapeutic antibodies developed for human DLL3, due to the high homology between primate and human proteins. Also utilized in pharmacokinetic and safety assessment studies in cynomolgus and rhesus macaque models to evaluate potential on-target toxicity of anti-DLL3 drug candidates.