Used in immunological research and drug development targeting Glypican-3 (GPC3), a protein overexpressed in several cancers such as hepatocellular carcinoma and melanoma. This recombinant protein with a His tag is employed in binding assays, antibody detection, and vaccine development. It serves as a critical tool for evaluating monoclonal antibodies and CAR-T cell therapies designed to recognize GPC3 in preclinical studies involving cynomolgus or rhesus macaque models. Its use helps assess cross-reactivity and therapeutic efficacy in non-human primates before human clinical trials.