Used in immunological research to study antibody-dependent cellular cytotoxicity (ADCC) mechanisms. Serves as a binding target for monoclonal antibodies and Fc-engineered therapeutics to evaluate effector function. Commonly employed in surface plasmon resonance (SPR) and ELISA assays to measure antibody affinity and Fc receptor interactions. Supports development and optimization of biologics, especially in preclinical testing where macaque models are used. The His Tag enables easy immobilization on nickel-based sensor chips or purification columns, facilitating high-throughput screening and characterization of therapeutic antibodies.