Used in immunological and oncology research to study angiogenesis and vascular remodeling. Serves as a biomarker in studies related to endothelial dysfunction and inflammatory diseases. Commonly employed in ELISA, Western blot, and neutralization assays to evaluate antibody binding and therapeutic agent efficacy. Facilitates cross-reactivity testing in preclinical development due to high homology with human ANGPT2. The His Tag allows for easy purification and detection in recombinant protein applications.