Used in immunological research to study the co-stimulatory and co-inhibitory pathways involved in T-cell activation. Serves as a critical reagent in assays evaluating immune checkpoint interactions, particularly in the development of immunotherapies for cancer and autoimmune diseases. Its Fc tag enables detection, purification, and potential dimerization, enhancing its utility in binding studies, ELISA, surface plasmon resonance, and cell-based functional assays. Frequently employed to assess receptor-ligand interactions with B7-H7 (HHLA2) and its putative receptors on immune cells, supporting drug discovery and mechanistic studies in primate models relevant to human immunity.