Used in immunology research to study T cell activation and immune responses in non-human primates. The Fc tag allows for detection and purification, making it valuable in assays such as ELISA, flow cytometry, and functional studies of T cell receptors. Commonly employed in preclinical testing of immunotherapies, including monoclonal antibodies and checkpoint inhibitors, due to the close similarity of macaque immune systems to humans. Supports development of biologics by enabling assessment of cross-reactivity and mechanism of action in relevant animal models.