Used in immunological research to study B cell activation and depletion mechanisms. Facilitates the development and testing of therapeutic antibodies targeting CD19, particularly in preclinical models for B cell malignancies and autoimmune diseases. The Fc tag enables detection, purification, and effector function assessment, making it valuable in immunoassays and binding studies involving Fc receptor-expressing cells. Commonly employed in flow cytometry, ELISA, and surface plasmon resonance to evaluate antibody binding kinetics and specificity in non-human primate models.