Used in immunological research to study the activation of γδ T cells, particularly Vγ9Vδ2 T cells, which play a role in immune responses against infections and tumors. The hFc tag enables easy detection and purification, making it valuable in binding assays, protein-protein interaction studies, and therapeutic antibody development. Commonly applied in ELISA, flow cytometry, and surface plasmon resonance (SPR) to analyze ligand binding and antibody affinity. Also supports the development of immunotherapies by helping characterize immune checkpoint pathways in non-human primate models.