Used in immunological research to study natural killer (NK) cell activation and immune checkpoint pathways. The His-tagged protein serves as a ligand for NCR3 (NKp30), enabling binding assays and interaction studies with immune receptors. Commonly applied in protein-protein interaction experiments, ELISA, and surface plasmon resonance (SPR) to measure binding affinity and kinetics. Supports development of immunotherapies by helping characterize NK cell-mediated responses in non-human primate models. Also used as an antigen to generate monoclonal antibodies targeting the B7-H6/NCR3LG1 pathway.