Used in biomedical research to study angiogenesis and vascular stability, particularly in models of inflammation, cancer, and ocular diseases. The Fc tag enables easy detection and purification, and facilitates binding studies with receptors or ligands in immunoassays such as ELISA, flow cytometry, and immunoprecipitation. Commonly employed in preclinical studies using cynomolgus or rhesus macaque models to evaluate therapeutic agents targeting the ANGPT-TIE signaling pathway. Supports development of biologics and assessment of cross-reactivity in translational research.