Used in immunoassays and molecular binding studies to detect and isolate CDH17-interacting proteins due to its biotin tag, which allows strong interaction with streptavidin-based detection systems. Commonly applied in ELISA, flow cytometry, and pull-down assays to study gastrointestinal cancer biomarkers, as CDH17 is overexpressed in colorectal and other carcinomas. The His tag enables efficient purification and immobilization on nickel-coated surfaces. Supports research in cell adhesion mechanisms and targeted therapy development.