D-Rhamnose is primarily used in biochemical and microbiological research due to its role as a component of bacterial cell wall polysaccharides, particularly in pathogenic microorganisms. It serves as a building block in the synthesis of complex antigens and glycoconjugates, making it valuable in vaccine development and immunological studies. Its presence in bacterial O-antigens allows researchers to study host-pathogen interactions and design synthetic analogs for diagnostic or therapeutic use. Additionally, D-rhamnose is employed in the preparation of labeled derivatives to track bacterial metabolism and cell wall biosynthesis. Its unique stereochemistry also makes it useful in chiral synthesis and the development of novel bioactive compounds.