Gadolinium(III) acetate tetrahydrate is primarily used as a precursor in the synthesis of gadolinium-based contrast agents for medical imaging in magnetic resonance imaging (MRI). These contrast agents enhance the quality of MRI scans by improving the visibility of internal body structures, making it easier to detect abnormalities such as tumors, inflammation, or vascular diseases.

In research, this compound is utilized in the synthesis of other gadolinium-based materials, which are explored for their magnetic and luminescent properties. It also finds application in materials science, where it is used to develop advanced ceramics and glass with unique optical characteristics.

Additionally, it serves as a precursor in the preparation of catalysts for organic reactions, particularly in processes requiring high selectivity and efficiency. Its role in nanotechnology is also noteworthy, as it is employed in the fabrication of nanoparticles for various biomedical and industrial applications. It may also be used in chemical and biochemical analysis to study molecular structures and reactions, as well as in the production of luminescent materials for applications like lamps and displays.