3-Iodoquinoline is primarily utilized in organic synthesis as a versatile building block for the construction of more complex quinoline derivatives. Its iodine atom serves as a reactive site for cross-coupling reactions, such as Suzuki, Sonogashira, and Heck reactions, enabling the introduction of various functional groups or aromatic systems. This compound is particularly valuable in pharmaceutical research for developing potential drug candidates, especially in the synthesis of antimalarial, anticancer, and antimicrobial agents. Additionally, it finds application in material science for the preparation of organic semiconductors and luminescent materials due to its electron-rich quinoline core. Its role in catalysis and as a ligand in coordination chemistry further highlights its importance in advancing chemical research and industrial processes.