8-Fluoroquinoline-5-sulfonylchloride
95%
Reagent
Code: #189563
CAS Number
1000933-89-0
blur_circular Chemical Specifications
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Molecular Information
Weight
245.66 g/mol
Formula
C₉H₅ClFNO₂S
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Storage & Handling
Storage
2-8°C
description Product Description
Used as a key intermediate in the synthesis of fluorinated quinoline-based compounds, particularly in pharmaceuticals and agrochemicals. Its sulfonyl chloride group readily reacts with nucleophiles like amines and alcohols, enabling the formation of sulfonamides and sulfonate esters. These derivatives are valuable in drug development for their enhanced bioavailability and metabolic stability. Commonly employed in the preparation of kinase inhibitors and antimicrobial agents due to the combined effects of the fluorine atom and quinoline scaffold. Also utilized in materials science for designing fluorescent probes and sensors, leveraging the electron-withdrawing fluorine and the inherent fluorescence of the quinoline ring.
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