4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate

95%

Reagent Code: #46215
fingerprint
CAS Number 788136-89-0

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 361.76 g/mol
Formula C₁₇H₁₃ClFN₃O₃
badge Registry Numbers
MDL Number MFCD11618121
thermostat Physical Properties
Boiling Point 471.5°C at 760 mmHg
inventory_2 Storage & Handling
Storage 2-8°C, protected from light, stored in an inert gas

description Product Description

This compound serves as a key intermediate in the synthesis of tyrosine kinase inhibitors, particularly epidermal growth factor receptor (EGFR) inhibitors used in targeted cancer therapies. It is employed in pharmaceutical research for the development of drugs like Gefitinib analogs, which target signaling pathways in cancer cells, such as those in lung, breast, and colorectal cancers. The acetate group at the 6-position protects the hydroxyl functionality during synthesis, allowing for subsequent modifications to enhance selectivity and efficacy. Preclinical studies of derived compounds have shown promise in halting cancer cell proliferation and overcoming resistance to existing treatments, with ongoing investigations into clinical applications.

shopping_cart Available Sizes & Pricing

Size Availability Unit Price Quantity
inventory 1g
10-20 days ฿1,116.00
inventory 5g
10-20 days ฿3,069.00
inventory 250mg
10-20 days ฿558.00

Cart

No products

Subtotal: 0.00
Total 0.00 THB