Used in pharmaceutical research as a key intermediate in the synthesis of kinase inhibitors, particularly targeting TRK (tropomyosin receptor kinase) proteins. It plays a critical role in the development of targeted cancer therapies, especially for tumors driven by NTRK gene fusions. Its structure enables selective binding and inhibition of TRK enzymes, contributing to antitumor activity in various solid tumors. Also explored in the design of central nervous system agents due to its ability to cross the blood-brain barrier.