2-Bromo-5-methylpyrimidine
98%
Reagent
Code: #145133
CAS Number
150010-20-1
blur_circular Chemical Specifications
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Molecular Information
Weight
173.01 g/mol
Formula
C₅H₅BrN₂
thermostat
Physical Properties
Boiling Point
265°C
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Storage & Handling
Storage
2-8°C
description Product Description
Used as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of kinase inhibitors and antiviral agents. Its structure, featuring a bromine at the activated 2-position of the pyrimidine ring, enables selective nucleophilic aromatic substitution (SNAr) and cross-coupling reactions, making it valuable in medicinal chemistry for constructing complex heterocyclic systems. Commonly employed in cross-coupling reactions such as Suzuki and Negishi couplings to form carbon-carbon bonds in drug discovery pipelines. Also utilized in agrochemical research for designing new active ingredients in crop protection products.
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