2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
≥95%
Reagent
Code: #187341
CAS Number
458532-86-0
science Other reagents with same CAS 458532-86-0
blur_circular Chemical Specifications
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Molecular Information
Weight
223.05 g/mol
Formula
C₁₁H₁₅BFNO₂
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Registry Numbers
MDL Number
MFCD06798253
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Physical Properties
Boiling Point
312.1±27.0 °C at 760 mmHg
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Storage & Handling
Storage
Room temperature, seal, dry, light-proof
description Product Description
Widely used in Suzuki-Miyaura cross-coupling reactions, this compound serves as a key building block in the synthesis of pharmaceuticals and agrochemicals. Its boronate ester group enables efficient carbon-carbon bond formation under mild conditions, making it valuable in medicinal chemistry for constructing biaryl systems. It is particularly useful in the development of kinase inhibitors and other bioactive molecules where a fluoropyridine moiety enhances metabolic stability and binding affinity. The presence of the fluorine atom also allows for further functionalization or labeling, including in PET tracer development. Its stability and reactivity profile make it a preferred reagent in both academic research and industrial drug discovery processes.
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