Used as an intermediate in the synthesis of pharmaceuticals, particularly in the development of nicotinamide-based bioactive compounds. The Weinreb amide moiety enables controlled addition reactions for ketone formation, while the 2-chloro substituent on the pyridine ring undergoes nucleophilic aromatic substitution, facilitating the assembly of complex derivatives. This makes it valuable in medicinal chemistry for creating drug candidates with enhanced properties, including potential applications in central nervous system therapeutics. Also employed in agrochemical research for designing novel active ingredients.