5-Bromo-N-methoxy-N-methylnicotinamide

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Reagent Code: #149762
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CAS Number 183608-47-1

science Other reagents with same CAS 183608-47-1

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Weight 245.07 g/mol
Formula C₈H₉BrN₂O₂
badge Registry Numbers
MDL Number MFCD07370042
inventory_2 Storage & Handling
Storage 2-8°C

description Product Description

Used as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of kinase inhibitors for cancer treatment. The N-methoxy-N-methyl group forms a Weinreb amide, which allows for selective ketone formation with organometallic reagents without over-addition, enhancing its utility in constructing complex carbonyl-containing structures. The bromine substituent at the 5-position of the pyridine ring enables selective functionalization through cross-coupling reactions such as Suzuki-Miyaura and Buchwald-Hartwig aminations, making it valuable in medicinal chemistry for creating analogs with improved biological activity and building drug-like molecules. Also utilized in agrochemical research for designing bioactive compounds with enhanced stability and target specificity.

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inventory 1g
10-20 days ฿7,540.00

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5-Bromo-N-methoxy-N-methylnicotinamide
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Used as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of kinase inhibitors for cancer treatment. The N-methoxy-N-methyl group forms a Weinreb amide, which allows for selective ketone formation with organometallic reagents without over-addition, enhancing its utility in constructing complex carbonyl-containing structures. The bromine substituent at the 5-position of the pyridine ring enables selective functionalization through cross-coupling reactions such as Suzu

Used as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of kinase inhibitors for cancer treatment. The N-methoxy-N-methyl group forms a Weinreb amide, which allows for selective ketone formation with organometallic reagents without over-addition, enhancing its utility in constructing complex carbonyl-containing structures. The bromine substituent at the 5-position of the pyridine ring enables selective functionalization through cross-coupling reactions such as Suzuki-Miyaura and Buchwald-Hartwig aminations, making it valuable in medicinal chemistry for creating analogs with improved biological activity and building drug-like molecules. Also utilized in agrochemical research for designing bioactive compounds with enhanced stability and target specificity.

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