5-Bromo-N-methoxy-N-methylnicotinamide
97%
science Other reagents with same CAS 183608-47-1
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Used as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of kinase inhibitors for cancer treatment. The N-methoxy-N-methyl group forms a Weinreb amide, which allows for selective ketone formation with organometallic reagents without over-addition, enhancing its utility in constructing complex carbonyl-containing structures. The bromine substituent at the 5-position of the pyridine ring enables selective functionalization through cross-coupling reactions such as Suzuki-Miyaura and Buchwald-Hartwig aminations, making it valuable in medicinal chemistry for creating analogs with improved biological activity and building drug-like molecules. Also utilized in agrochemical research for designing bioactive compounds with enhanced stability and target specificity.
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