1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride
98%
Reagent
Code: #187830
Alias
Vili watermelon intermediate; Vilisigua intermediate; Vilisigua intermediate; Leosigua intermediate
CAS Number
256499-19-1
science Other reagents with same CAS 256499-19-1
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Molecular Information
Weight
305.74 g/mol
Formula
C₁₄H₁₃ClFN₅
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Registry Numbers
MDL Number
MFCD18432772
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Storage & Handling
Storage
Room temperature, dry
description Product Description
Used in pharmaceutical research as a key intermediate in the synthesis of kinase inhibitors, particularly those targeting JAK (Janus kinase) and other tyrosine kinases involved in inflammatory and autoimmune diseases. Exhibits potential in the development of treatments for conditions such as rheumatoid arthritis, psoriasis, and certain cancers due to its role in modulating signaling pathways. Its structure allows for high selectivity and binding affinity to enzyme active sites, making it valuable in optimizing drug candidates for improved efficacy and reduced off-target effects. Also employed in structure-activity relationship (SAR) studies to enhance metabolic stability and solubility of related compounds.
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