4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole
97%
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Widely used in cross-coupling reactions, this compound serves as a key boronic ester reagent in Suzuki-Miyaura coupling, enabling the formation of carbon-carbon bonds in pharmaceutical and agrochemical synthesis. Its pyrazole core is common in bioactive molecules, making it valuable for constructing drug-like structures. The trifluoroethyl group enhances metabolic stability and lipophilicity, which is beneficial in medicinal chemistry for improving pharmacokinetic properties. It is particularly useful in the development of kinase inhibitors and other targeted therapies. Additionally, its boronate functionality allows for rapid diversification through late-stage functionalization in compound libraries for high-throughput screening.
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