3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole

95%

Reagent Code: #238405
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CAS Number 2915301-91-4

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 276.06 g/mol
Formula C₁₁H₁₆BF₃N₂O₂
badge Registry Numbers
MDL Number MFCD24540322
inventory_2 Storage & Handling
Storage 2-8°C, Inert Gas

description Product Description

Widely used in Suzuki-Miyaura cross-coupling reactions, this compound serves as a key boronic ester reagent for constructing carbon-carbon bonds in pharmaceutical and agrochemical synthesis. Its pyrazole core is a common pharmacophore, making it valuable for developing bioactive molecules. The trifluoroethyl group enhances metabolic stability and lipophilicity, which is beneficial in drug design. It is particularly useful in the preparation of kinase inhibitors and other medicinal agents where fluorinated heterocycles improve potency and pharmacokinetic properties. The boronate ester functionality allows for mild, palladium-catalyzed coupling with aryl or heteroaryl halides, enabling efficient library synthesis in medicinal chemistry campaigns.

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Size Availability Unit Price Quantity
inventory 100mg
10-20 days ฿10,180.00
inventory 250mg
10-20 days ฿16,290.00
inventory 1g
10-20 days ฿42,350.00

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