Pyrazine 1-oxide is primarily utilized in the field of organic synthesis as a versatile intermediate. It plays a significant role in the development of pharmaceuticals, particularly in the synthesis of compounds with potential antibacterial and antifungal properties. Its unique structure allows it to act as a building block for more complex molecules, aiding in the creation of drugs targeting various diseases. Additionally, it is employed in agrochemical research for designing new pesticides and herbicides, leveraging its reactivity to enhance efficacy. In material science, Pyrazine 1-oxide contributes to the development of advanced materials, such as organic semiconductors, due to its electronic properties. Its applications also extend to the study of coordination chemistry, where it is used to synthesize metal-organic frameworks (MOFs) with potential applications in gas storage and catalysis.