2-amino-9-((1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-1H-purin-6(9H)-one
97%
blur_circular Chemical Specifications
description Product Description
This compound serves as a key protected intermediate in the synthesis of Entecavir, a guanosine nucleoside analog used in antiviral medications primarily for the treatment of chronic hepatitis B virus (HBV) infections. Its structure, featuring a modified cyclopentyl moiety with benzyl protecting groups, facilitates the development of the active pharmaceutical ingredient. Once deprotected, the resulting nucleoside analog inhibits HBV DNA polymerase (which possesses reverse transcriptase activity), thereby suppressing viral replication by chain termination and competition with natural nucleosides. It has been extensively studied for its efficacy against HBV and is a promising component in oral antiviral therapies. This intermediate's unique chemical architecture supports advanced pharmaceutical research and manufacturing processes for HBV treatments.
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| Test Parameter | Specification |
|---|---|
| Appearance | White to Off-white to Pale beige to Grey to Yellow Powder or Crystals |
| Purity (%) | 96.5-100 |
| Water (%) | 0-1.0 |
| Infrared Spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
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