2-amino-9-((1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-1H-purin-6(9H)-one

97%

Reagent Code: #42517
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CAS Number 142217-81-0

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 457.54 g/mol
Formula C₂₆H₂₇N₅O₃
badge Registry Numbers
MDL Number MFCD11977291
inventory_2 Storage & Handling
Density 1.34g/mL
Storage room temperature, dry

description Product Description

This compound serves as a key protected intermediate in the synthesis of Entecavir, a guanosine nucleoside analog used in antiviral medications primarily for the treatment of chronic hepatitis B virus (HBV) infections. Its structure, featuring a modified cyclopentyl moiety with benzyl protecting groups, facilitates the development of the active pharmaceutical ingredient. Once deprotected, the resulting nucleoside analog inhibits HBV DNA polymerase (which possesses reverse transcriptase activity), thereby suppressing viral replication by chain termination and competition with natural nucleosides. It has been extensively studied for its efficacy against HBV and is a promising component in oral antiviral therapies. This intermediate's unique chemical architecture supports advanced pharmaceutical research and manufacturing processes for HBV treatments.

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Test Parameter Specification
Appearance White to Off-white to Pale beige to Grey to Yellow Powder or Crystals
Purity (%) 96.5-100
Water (%) 0-1.0
Infrared Spectrum Conforms to Structure
NMR Conforms to Structure

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Size Availability Unit Price Quantity
inventory 1g
10-20 days ฿4,554.00

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