(Trimethylsilyl)acetonitrile is primarily used in organic synthesis as a versatile reagent and nucleophilic equivalent of acetonitrile for introducing the cyanomethyl group and forming carbon-carbon bonds. It is employed in the preparation of silicon-containing compounds valuable in materials science and pharmaceuticals. Additionally, it serves as a key intermediate in the synthesis of heterocycles and other complex organic molecules. Its stability and controlled reactivity make it an essential tool in advanced chemical transformations.