(3-Bromo-4-methylphenoxy)(tert-butyl)dimethylsilane
97%
science Other reagents with same CAS 164513-48-8
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description Product Description
(3-Bromo-4-methylphenoxy)(tert-butyl)dimethylsilane is a protected derivative of 3-bromo-4-methylphenol, featuring a tert-butyldimethylsilyl (TBDMS) group on the phenolic oxygen. This compound serves as a key intermediate in organic synthesis, enabling selective functionalization of the aromatic ring, such as through palladium-catalyzed cross-coupling reactions at the bromo position, while the hydroxyl group remains masked. It is particularly useful in the multi-step synthesis of pharmaceuticals, agrochemicals, and advanced materials. The TBDMS protecting group provides stability during reactions and can be readily removed under mild acidic or fluoride conditions to afford the free phenol.
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