(3-Bromo-4-methylphenoxy)(tert-butyl)dimethylsilane
97%
Reagent
Code: #36687
CAS Number
164513-48-8
blur_circular Chemical Specifications
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Molecular Information
Weight
301.30 g/mol
Formula
C₁₃H₂₁BrOSi
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Registry Numbers
MDL Number
MFCD24847837
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Physical Properties
Boiling Point
293.6±28.0°C at 760 mmHg
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Storage & Handling
Storage
Room temperature, dry and sealed
description Product Description
(3-Bromo-4-methylphenoxy)(tert-butyl)dimethylsilane is a protected derivative of 3-bromo-4-methylphenol, featuring a tert-butyldimethylsilyl (TBDMS) group on the phenolic oxygen. This compound serves as a key intermediate in organic synthesis, enabling selective functionalization of the aromatic ring, such as through palladium-catalyzed cross-coupling reactions at the bromo position, while the hydroxyl group remains masked. It is particularly useful in the multi-step synthesis of pharmaceuticals, agrochemicals, and advanced materials. The TBDMS protecting group provides stability during reactions and can be readily removed under mild acidic or fluoride conditions to afford the free phenol.
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