Used as a highly effective sulfonylating agent in organic synthesis, particularly for introducing the 2,4,6-triisopropylbenzenesulfonyl (TRIS) group. It is favored in peptide chemistry and nucleotide modification due to its ability to selectively protect hydroxyl and amino groups. The bulky triisopropylbenzene moiety enhances steric shielding, improving selectivity and stability of intermediates. Commonly applied in the preparation of complex natural products and pharmaceuticals where controlled activation and protection are required. Its reactivity with alcohols and amines under mild conditions makes it valuable in multi-step syntheses.