tert-Butyldimethylsilyl chloride solution
1.0 M in THF
science Other reagents with same CAS 18162-48-6
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description Product Description
Widely used in organic synthesis as a silyl protecting group reagent, particularly for alcohols and phenols. It selectively protects hydroxyl groups, enhancing stability during multi-step reactions. Commonly employed in the synthesis of complex molecules like natural products and pharmaceuticals, where protection of polar functional groups is essential. Its bulky structure provides steric hindrance, offering good selectivity and resistance to unwanted deprotection. Stable under a variety of reaction conditions, it allows for compatibility with oxidation, reduction, and coupling reactions. Deprotection is typically achieved under mild acidic conditions or with fluoride sources like TBAF, making it versatile and reliable in synthetic strategies.
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