tert-Butyldimethylsilyl 2-bromoacetate

95%

Reagent Code: #130394
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CAS Number 480439-46-1

science Other reagents with same CAS 480439-46-1

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 253.21 g/mol
Formula C₈H₁₇BrO₂Si
badge Registry Numbers
MDL Number MFCD04039979
thermostat Physical Properties
Melting Point 175-189 °C
inventory_2 Storage & Handling
Storage 2-8°C, Sealed, Inert Gas

description Product Description

Used as a silyl protecting group reagent in organic synthesis, particularly in the protection of alcohols and hydroxyl groups during multi-step synthesis of complex molecules such as natural products and pharmaceuticals. The tert-butyldimethylsilyl (TBS) group provides stability under a variety of reaction conditions while being selectively removable under mild acidic or fluoride ion conditions. The presence of the 2-bromoacetate moiety allows for further functionalization, enabling the introduction of bromoalkyl units that can participate in subsequent alkylation or cyclization reactions. Commonly employed in carbohydrate chemistry and nucleoside synthesis where selective protection is critical. Its reactivity also makes it useful in the preparation of bifunctional intermediates for medicinal chemistry and polymer synthesis.

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Size Availability Unit Price Quantity
inventory 1g
10-20 days ฿7,830.00
inventory 250mg
10-20 days ฿2,910.00

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tert-Butyldimethylsilyl 2-bromoacetate
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Used as a silyl protecting group reagent in organic synthesis, particularly in the protection of alcohols and hydroxyl groups during multi-step synthesis of complex molecules such as natural products and pharmaceuticals. The tert-butyldimethylsilyl (TBS) group provides stability under a variety of reaction conditions while being selectively removable under mild acidic or fluoride ion conditions. The presence of the 2-bromoacetate moiety allows for further functionalization, enabling the introduction of b

Used as a silyl protecting group reagent in organic synthesis, particularly in the protection of alcohols and hydroxyl groups during multi-step synthesis of complex molecules such as natural products and pharmaceuticals. The tert-butyldimethylsilyl (TBS) group provides stability under a variety of reaction conditions while being selectively removable under mild acidic or fluoride ion conditions. The presence of the 2-bromoacetate moiety allows for further functionalization, enabling the introduction of bromoalkyl units that can participate in subsequent alkylation or cyclization reactions. Commonly employed in carbohydrate chemistry and nucleoside synthesis where selective protection is critical. Its reactivity also makes it useful in the preparation of bifunctional intermediates for medicinal chemistry and polymer synthesis.

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