Z-Glycinol, or N-(benzyloxycarbonyl)glycinol, is a protected derivative of glycinol (2-aminoethanol) primarily used in organic synthesis, particularly for peptide and peptidomimetic construction. The Z (Cbz) protecting group shields the amino functionality, enabling selective manipulation of the hydroxyl group or incorporation as a C-terminal mimic in peptide chains. This prevents side reactions during bond formation, ensuring precise control over the molecular architecture. It is especially valuable in synthesizing complex peptides, proteins, and bioactive compounds for medicinal chemistry and drug development. The Z group’s stability and facile removal via mild hydrogenation make Z-Glycinol an essential intermediate in these applications.