This chemical is primarily utilized in peptide synthesis as a protecting group for histidine residues. It helps to prevent unwanted side reactions during the coupling of amino acids, ensuring the accuracy and efficiency of peptide chain assembly. The tert-butyldiphenylsilyl group protects the hydroxyl moiety, while the triisopropylbenzenesulfonyl group shields the imidazole ring of histidine. This dual protection is particularly useful in complex peptide synthesis, where selective deprotection can be achieved without disrupting the overall structure. Its application is crucial in the production of bioactive peptides, pharmaceuticals, and research compounds where precise control over peptide assembly is required.