Boc-L-His(Tos)-OH is widely used in peptide synthesis as a protected form of histidine. It serves as a key intermediate in the production of peptides, ensuring the histidine residue remains stable during the synthesis process. This compound is particularly valuable in solid-phase peptide synthesis (SPPS), where it helps prevent unwanted side reactions. Its applications extend to the development of pharmaceuticals, including peptide-based drugs, where precise control over amino acid incorporation is crucial. Additionally, it is utilized in research for studying protein structure and function, as well as in the creation of custom peptides for biochemical assays.