Used in peptide synthesis as a protected building block for oxidized methionine (methionine sulfone, Met(O2)), particularly in solid-phase peptide synthesis (SPPS). The Fmoc group protects the amino group, while the sulfone moiety provides stability and prevents unwanted side reactions during synthesis, allowing for the controlled incorporation of an oxidized methionine residue. It is especially useful in creating peptides that mimic oxidative modifications or require stable methionine analogs. After synthesis, the Fmoc group can be removed under mild basic conditions, and the sulfone can be reduced if needed, enabling further modification or deprotection of the peptide.

This compound is also valuable in biochemical studies of methionine oxidation, such as investigating oxidative stress effects on proteins and peptides, which is relevant to research on diseases involving cellular degradation. Overall, it supports precise peptide engineering for applications in research, pharmaceuticals, and biotechnology.